diff --git a/cms/envs/acceptance.py b/cms/envs/acceptance.py
index 62a42cb3f6..80a00b0e10 100644
--- a/cms/envs/acceptance.py
+++ b/cms/envs/acceptance.py
@@ -121,3 +121,7 @@ except ImportError:
 YOUTUBE['API'] = "127.0.0.1:{0}/get_youtube_api/".format(YOUTUBE_PORT)
 YOUTUBE['TEST_URL'] = "127.0.0.1:{0}/test_youtube/".format(YOUTUBE_PORT)
 YOUTUBE['TEXT_API']['url'] = "127.0.0.1:{0}/test_transcripts_youtube/".format(YOUTUBE_PORT)
+
+# Generate a random UUID so that different runs of acceptance tests don't break each other
+import uuid
+SECRET_KEY = uuid.uuid4().hex
diff --git a/cms/envs/bok_choy.py b/cms/envs/bok_choy.py
index 0eaf66155f..eb5e32193b 100644
--- a/cms/envs/bok_choy.py
+++ b/cms/envs/bok_choy.py
@@ -84,6 +84,10 @@ MOCK_SEARCH_BACKING_FILE = (
     TEST_ROOT / "index_file.dat"  # pylint: disable=no-value-for-parameter
 ).abspath()
 
+# Generate a random UUID so that different runs of acceptance tests don't break each other
+import uuid
+SECRET_KEY = uuid.uuid4().hex
+
 #####################################################################
 # Lastly, see if the developer has any local overrides.
 try:
diff --git a/cms/envs/devstack.py b/cms/envs/devstack.py
index abb9abfa01..d6dec86160 100644
--- a/cms/envs/devstack.py
+++ b/cms/envs/devstack.py
@@ -93,3 +93,6 @@ except ImportError:
 #####################################################################
 # Lastly, run any migrations, if needed.
 MODULESTORE = convert_module_store_setting_if_needed(MODULESTORE)
+
+# Dummy secret key for dev
+SECRET_KEY = '85920908f28904ed733fe576320db18cabd7b6cd'
diff --git a/cms/envs/test.py b/cms/envs/test.py
index ecc9369277..4ea673698f 100644
--- a/cms/envs/test.py
+++ b/cms/envs/test.py
@@ -238,7 +238,6 @@ FEATURES['USE_MICROSITES'] = True
 # the one in lms/envs/test.py
 FEATURES['ENABLE_DISCUSSION_SERVICE'] = False
 
-
 # Enable content libraries code for the tests
 FEATURES['ENABLE_CONTENT_LIBRARIES'] = True
 
@@ -262,3 +261,6 @@ SEARCH_ENGINE = "search.tests.mock_search_engine.MockSearchEngine"
 MOCK_SEARCH_BACKING_FILE = (
     TEST_ROOT / "index_file.dat"  # pylint: disable=no-value-for-parameter
 ).abspath()
+
+# Dummy secret key for dev/test
+SECRET_KEY = '85920908f28904ed733fe576320db18cabd7b6cd'
diff --git a/lms/envs/acceptance.py b/lms/envs/acceptance.py
index c87aee700a..98eaa48590 100644
--- a/lms/envs/acceptance.py
+++ b/lms/envs/acceptance.py
@@ -183,3 +183,7 @@ YOUTUBE['TEXT_API']['url'] = "127.0.0.1:{0}/test_transcripts_youtube/".format(YO
 if FEATURES.get('ENABLE_COURSEWARE_SEARCH'):
     # Use MockSearchEngine as the search engine for test scenario
     SEARCH_ENGINE = "search.tests.mock_search_engine.MockSearchEngine"
+
+# Generate a random UUID so that different runs of acceptance tests don't break each other
+import uuid
+SECRET_KEY = uuid.uuid4().hex
diff --git a/lms/envs/bok_choy.py b/lms/envs/bok_choy.py
index 9517e63e5e..8cfd1e48d9 100644
--- a/lms/envs/bok_choy.py
+++ b/lms/envs/bok_choy.py
@@ -127,6 +127,10 @@ MOCK_SEARCH_BACKING_FILE = (
     TEST_ROOT / "index_file.dat"  # pylint: disable=no-value-for-parameter
 ).abspath()
 
+# Generate a random UUID so that different runs of acceptance tests don't break each other
+import uuid
+SECRET_KEY = uuid.uuid4().hex
+
 #####################################################################
 # Lastly, see if the developer has any local overrides.
 try:
diff --git a/lms/envs/devstack.py b/lms/envs/devstack.py
index 2b1f2e5730..8f648ff310 100644
--- a/lms/envs/devstack.py
+++ b/lms/envs/devstack.py
@@ -134,3 +134,5 @@ except ImportError:
 #####################################################################
 # Lastly, run any migrations, if needed.
 MODULESTORE = convert_module_store_setting_if_needed(MODULESTORE)
+
+SECRET_KEY = '85920908f28904ed733fe576320db18cabd7b6cd'