diff --git a/common/djangoapps/course_modes/models.py b/common/djangoapps/course_modes/models.py
index 4046877c15..11a97b24ea 100644
--- a/common/djangoapps/course_modes/models.py
+++ b/common/djangoapps/course_modes/models.py
@@ -550,6 +550,32 @@ class CourseMode(models.Model):
         """
         return slug in [cls.PROFESSIONAL, cls.NO_ID_PROFESSIONAL_MODE]
 
+    @classmethod
+    def contains_masters_mode(cls, modes_dict):
+        """
+        Check whether the modes_dict contains a Master's mode.
+
+        Args:
+            modes_dict (dict): a dict of course modes
+
+        Returns:
+            bool: whether modes_dict contains a Master's mode
+        """
+        return cls.MASTERS in modes_dict
+
+    @classmethod
+    def is_masters_only(cls, course_id):
+        """
+        Check whether the course contains only a Master's mode.
+
+        Args:
+            course_id (CourseKey): course key of course to check
+
+        Returns: bool: whether the course contains only a Master's mode
+        """
+        modes = cls.modes_for_course_dict(course_id)
+        return cls.contains_masters_mode(modes) and len(modes) == 1
+
     @classmethod
     def is_mode_upgradeable(cls, mode_slug):
         """
diff --git a/common/djangoapps/course_modes/tests/test_models.py b/common/djangoapps/course_modes/tests/test_models.py
index 596c2fbd42..6055be65e8 100644
--- a/common/djangoapps/course_modes/tests/test_models.py
+++ b/common/djangoapps/course_modes/tests/test_models.py
@@ -486,6 +486,33 @@ class CourseModeModelTest(TestCase):
         else:
             self.assertFalse(is_error_expected, "Expected a ValidationError to be thrown.")
 
+    @ddt.data(
+        ([], False),
+        ([CourseMode.VERIFIED, CourseMode.AUDIT], False),
+        ([CourseMode.MASTERS], True),
+        ([CourseMode.VERIFIED, CourseMode.AUDIT, CourseMode.MASTERS], True)
+    )
+    @ddt.unpack
+    def test_contains_masters_mode(self, available_modes, expected_contains_masters_mode):
+        for mode in available_modes:
+            self.create_mode(mode, mode, 10)
+
+        modes = CourseMode.modes_for_course_dict(self.course_key)
+        self.assertEqual(CourseMode.contains_masters_mode(modes), expected_contains_masters_mode)
+
+    @ddt.data(
+        ([], False),
+        ([CourseMode.VERIFIED, CourseMode.AUDIT], False),
+        ([CourseMode.MASTERS], True),
+        ([CourseMode.VERIFIED, CourseMode.AUDIT, CourseMode.MASTERS], False)
+    )
+    @ddt.unpack
+    def test_is_masters_only(self, available_modes, expected_is_masters_only):
+        for mode in available_modes:
+            self.create_mode(mode, mode, 10)
+
+        self.assertEqual(CourseMode.is_masters_only(self.course_key), expected_is_masters_only)
+
 
 class TestDisplayPrices(ModuleStoreTestCase):
     @override_settings(PAID_COURSE_REGISTRATION_CURRENCY=["USD", "$"])
diff --git a/lms/djangoapps/courseware/tests/test_views.py b/lms/djangoapps/courseware/tests/test_views.py
index a020a5af79..9671f7c3df 100644
--- a/lms/djangoapps/courseware/tests/test_views.py
+++ b/lms/djangoapps/courseware/tests/test_views.py
@@ -18,7 +18,7 @@ from django.conf import settings
 from django.contrib.auth.models import AnonymousUser
 from django.urls import reverse, reverse_lazy
 from django.http import Http404, HttpResponseBadRequest
-from django.test import TestCase
+from django.test import TestCase, RequestFactory
 from django.test.client import Client
 from django.test.utils import override_settings
 from freezegun import freeze_time
@@ -2517,6 +2517,56 @@ class TestIndexView(ModuleStoreTestCase):
                     self.assertIn('xblock-student_view-html', response.content)
                     self.assertIn('xblock-student_view-video', response.content)
 
+    @patch('openedx.core.djangoapps.util.user_messages.PageLevelMessages.register_warning_message')
+    def test_courseware_messages_masters_only(self, patch_register_warning_message):
+        with patch('courseware.views.views.CourseTabView.should_show_enroll_button') as patch_should_show_enroll_button:
+            course = CourseFactory()
+
+            user = self.create_user_for_course(course, CourseUserType.UNENROLLED)
+            request = RequestFactory().get('/')
+            request.user = user
+
+            button_html = '<button class="enroll-btn btn-link">Enroll now</button>'
+
+            patch_should_show_enroll_button.return_value = False
+            views.CourseTabView.register_user_access_warning_messages(request, course)
+            # pull message out of the calls to the mock so that
+            # we can make finer grained assertions than mock provides
+            message = patch_register_warning_message.mock_calls[0][1][1]
+            assert button_html not in message
+
+            patch_register_warning_message.reset_mock()
+
+            patch_should_show_enroll_button.return_value = True
+            views.CourseTabView.register_user_access_warning_messages(request, course)
+            # pull message out of the calls to the mock so that
+            # we can make finer grained assertions than mock provides
+            message = patch_register_warning_message.mock_calls[0][1][1]
+            assert button_html in message
+
+    @ddt.data(
+        [True, True, True, False, ],
+        [False, True, True, False, ],
+        [True, False, True, False, ],
+        [True, True, False, False, ],
+        [False, False, True, False, ],
+        [True, False, False, True, ],
+        [False, True, False, False, ],
+        [False, False, False, False, ],
+    )
+    @ddt.unpack
+    def test_should_show_enroll_button(self, course_open_for_self_enrollment,
+                                       invitation_only, is_masters_only, expected_should_show_enroll_button):
+        with patch('courseware.views.views.course_open_for_self_enrollment') as patch_course_open_for_self_enrollment, \
+                patch('course_modes.models.CourseMode.is_masters_only') as patch_is_masters_only:
+            course = CourseFactory()
+
+            patch_course_open_for_self_enrollment.return_value = course_open_for_self_enrollment
+            patch_is_masters_only.return_value = is_masters_only
+            course.invitation_only = invitation_only
+
+            self.assertEqual(views.CourseTabView.should_show_enroll_button(course), expected_should_show_enroll_button)
+
 
 @ddt.ddt
 class TestIndexViewCompleteOnView(ModuleStoreTestCase, CompletionWaffleTestMixin):
diff --git a/lms/djangoapps/courseware/views/views.py b/lms/djangoapps/courseware/views/views.py
index c8ec728af5..dd8b73a9b1 100644
--- a/lms/djangoapps/courseware/views/views.py
+++ b/lms/djangoapps/courseware/views/views.py
@@ -551,7 +551,7 @@ class CourseTabView(EdxFragmentView):
         else:
             if not CourseEnrollment.is_enrolled(request.user, course.id) and not allow_anonymous:
                 # Only show enroll button if course is open for enrollment.
-                if course_open_for_self_enrollment(course.id) and not course.invitation_only:
+                if CourseTabView.should_show_enroll_button(course):
                     enroll_message = _(u'You must be enrolled in the course to see course content. \
                             {enroll_link_start}Enroll now{enroll_link_end}.')
                     PageLevelMessages.register_warning_message(
@@ -567,6 +567,12 @@ class CourseTabView(EdxFragmentView):
                         Text(_('You must be enrolled in the course to see course content.'))
                     )
 
+    @staticmethod
+    def should_show_enroll_button(course):
+        return (course_open_for_self_enrollment(course.id)
+                and not course.invitation_only
+                and not CourseMode.is_masters_only(course.id))
+
     @staticmethod
     def handle_exceptions(request, course_key, course, exception):
         u"""
diff --git a/openedx/features/course_experience/tests/views/helpers.py b/openedx/features/course_experience/tests/views/helpers.py
index 24922add83..435d562862 100644
--- a/openedx/features/course_experience/tests/views/helpers.py
+++ b/openedx/features/course_experience/tests/views/helpers.py
@@ -3,6 +3,7 @@ Test helpers for the course experience.
 """
 from datetime import timedelta
 
+from django.core.exceptions import ObjectDoesNotExist
 from django.utils.timezone import now
 
 from course_modes.models import CourseMode
@@ -10,9 +11,16 @@ from course_modes.models import CourseMode
 TEST_COURSE_PRICE = 50
 
 
-def add_course_mode(course, upgrade_deadline_expired=False):
+def add_course_mode(course, mode_slug=CourseMode.VERIFIED,
+                    mode_display_name='Verified Certificate', upgrade_deadline_expired=False):
     """
-    Adds a course mode to the test course.
+    Add a course mode to the test course.
+
+    Args:
+        course
+        mode_slug (str): the slug of the mode to add
+        mode_display_name (str): the display name of the mode to add
+        upgrade_deadline_expired (bool): whether the upgrade deadline has passed
     """
     upgrade_exp_date = now()
     if upgrade_deadline_expired:
@@ -22,8 +30,24 @@ def add_course_mode(course, upgrade_deadline_expired=False):
 
     CourseMode(
         course_id=course.id,
-        mode_slug=CourseMode.VERIFIED,
-        mode_display_name="Verified Certificate",
+        mode_slug=mode_slug,
+        mode_display_name=mode_display_name,
         min_price=TEST_COURSE_PRICE,
         _expiration_datetime=upgrade_exp_date,
     ).save()
+
+
+def remove_course_mode(course, mode_slug):
+    """
+    Remove a course mode from the test course if it exists in the course.
+
+    Args:
+        course
+        mode_slug (str): slug of the mode to remove
+    """
+    try:
+        mode = CourseMode.objects.get(course_id=course.id, mode_slug=mode_slug)
+    except ObjectDoesNotExist:
+        pass
+
+    mode.delete()
diff --git a/openedx/features/course_experience/tests/views/test_course_home.py b/openedx/features/course_experience/tests/views/test_course_home.py
index 41ea43f3f5..ba9730a022 100644
--- a/openedx/features/course_experience/tests/views/test_course_home.py
+++ b/openedx/features/course_experience/tests/views/test_course_home.py
@@ -58,7 +58,7 @@ from xmodule.modulestore.tests.django_utils import CourseUserType, ModuleStoreTe
 from xmodule.modulestore.tests.factories import CourseFactory, ItemFactory, check_mongo_calls
 
 from ... import COURSE_PRE_START_ACCESS_FLAG, ENABLE_COURSE_GOALS
-from .helpers import add_course_mode
+from .helpers import add_course_mode, remove_course_mode
 from .test_course_updates import create_course_update, remove_course_updates
 
 TEST_PASSWORD = 'test'
@@ -656,6 +656,34 @@ class TestCourseHomePageAccess(CourseHomePageTestCase):
         response = self.client.get(url)
         self.assertEqual(response.status_code, 404)
 
+    @override_waffle_flag(COURSE_PRE_START_ACCESS_FLAG, active=True)
+    def test_masters_course_message(self):
+        enroll_button_html = "<button class=\"enroll-btn btn-link\">Enroll now</button>"
+
+        # Verify that unenrolled users visiting a course with a Master's track
+        # that is not the only track are shown an enroll call to action message
+        add_course_mode(self.course, CourseMode.MASTERS, 'Master\'s Mode', upgrade_deadline_expired=False)
+
+        self.create_user_for_course(self.course, CourseUserType.UNENROLLED)
+        url = course_home_url(self.course)
+        response = self.client.get(url)
+
+        self.assertContains(response, TEST_COURSE_HOME_MESSAGE)
+        self.assertContains(response, TEST_COURSE_HOME_MESSAGE_UNENROLLED)
+        self.assertContains(response, enroll_button_html)
+
+        # Verify that unenrolled users visiting a course that contains only a Master's track
+        # are not shown an enroll call to action message
+        remove_course_mode(self.course, CourseMode.VERIFIED)
+
+        response = self.client.get(url)
+
+        expected_message = ('You must be enrolled in the course to see course content. '
+                            'Please contact your degree administrator or edX Support if you have questions.')
+        self.assertContains(response, TEST_COURSE_HOME_MESSAGE)
+        self.assertContains(response, expected_message)
+        self.assertNotContains(response, enroll_button_html)
+
     @override_waffle_flag(COURSE_PRE_START_ACCESS_FLAG, active=True)
     def test_course_messaging(self):
         """
diff --git a/openedx/features/course_experience/views/course_home_messages.py b/openedx/features/course_experience/views/course_home_messages.py
index 084f2f296e..56521f2711 100644
--- a/openedx/features/course_experience/views/course_home_messages.py
+++ b/openedx/features/course_experience/views/course_home_messages.py
@@ -5,6 +5,7 @@ View logic for handling course messages.
 from datetime import datetime
 
 from babel.dates import format_date, format_timedelta
+from course_modes.models import CourseMode
 from courseware.courses import get_course_date_blocks, get_course_with_access
 from django.contrib import auth
 from django.template.loader import render_to_string
@@ -129,7 +130,20 @@ def _register_course_home_messages(request, course, user_access, course_start_da
         )
     if not user_access['is_anonymous'] and not user_access['is_staff'] and \
             not user_access['is_enrolled']:
-        if not course.invitation_only:
+
+        title = Text(_(u'Welcome to {course_display_name}')).format(
+            course_display_name=course.display_name
+        )
+
+        if CourseMode.is_masters_only(course.id):
+            # if a course is a Master's only course, we will not offer user ability to self-enroll
+            CourseHomeMessages.register_info_message(
+                request,
+                Text(_('You must be enrolled in the course to see course content. '
+                       'Please contact your degree administrator or edX Support if you have questions.')),
+                title=title
+            )
+        elif not course.invitation_only:
             CourseHomeMessages.register_info_message(
                 request,
                 Text(_(
@@ -138,9 +152,7 @@ def _register_course_home_messages(request, course, user_access, course_start_da
                     open_enroll_link=HTML('<button class="enroll-btn btn-link">'),
                     close_enroll_link=HTML('</button>')
                 ),
-                title=Text(_(u'Welcome to {course_display_name}')).format(
-                    course_display_name=course.display_name
-                )
+                title=title
             )
         else:
             CourseHomeMessages.register_info_message(