diff --git a/requirements/edx/base.txt b/requirements/edx/base.txt
index ce59f16b52..07d76d760c 100644
--- a/requirements/edx/base.txt
+++ b/requirements/edx/base.txt
@@ -246,3 +246,6 @@ xblock-utils==1.2.1
 xblock==1.2.2
 xmlsec==1.3.3             # via python3-saml
 zendesk==1.1.1
+
+# The following packages are considered to be unsafe in a requirements file:
+# setuptools==41.0.1        # via fs, lazy, python-levenshtein
diff --git a/requirements/edx/development.txt b/requirements/edx/development.txt
index b24bbb4cdd..1600d2412a 100644
--- a/requirements/edx/development.txt
+++ b/requirements/edx/development.txt
@@ -335,3 +335,6 @@ xmlsec==1.3.3
 xmltodict==0.12.0
 zendesk==1.1.1
 zipp==0.5.1
+
+# The following packages are considered to be unsafe in a requirements file:
+# setuptools==41.0.1        # via caniusepython3, fs, lazy, pytest, python-levenshtein, sphinx, tox
diff --git a/requirements/edx/paver.txt b/requirements/edx/paver.txt
index 3bde400daa..8e4a1674bc 100644
--- a/requirements/edx/paver.txt
+++ b/requirements/edx/paver.txt
@@ -27,3 +27,6 @@ stevedore==1.30.1
 urllib3==1.23             # via requests
 watchdog==0.9.0
 wrapt==1.10.5
+
+# The following packages are considered to be unsafe in a requirements file:
+# setuptools==41.0.1        # via lazy
diff --git a/requirements/edx/testing.txt b/requirements/edx/testing.txt
index 615ddc295e..2b0f422441 100644
--- a/requirements/edx/testing.txt
+++ b/requirements/edx/testing.txt
@@ -321,3 +321,6 @@ xmlsec==1.3.3
 xmltodict==0.12.0         # via moto
 zendesk==1.1.1
 zipp==0.5.1               # via importlib-metadata
+
+# The following packages are considered to be unsafe in a requirements file:
+# setuptools==41.0.1        # via caniusepython3, fs, lazy, pytest, python-levenshtein, tox