diff --git a/lms/djangoapps/mobile_api/course_info/tests.py b/lms/djangoapps/mobile_api/course_info/tests.py
index 40a0a3ed28..490f530299 100644
--- a/lms/djangoapps/mobile_api/course_info/tests.py
+++ b/lms/djangoapps/mobile_api/course_info/tests.py
@@ -185,7 +185,7 @@ class TestHandouts(MobileAPITestCase, MobileAuthTestMixin, MobileCourseAccessTes
 
             # but shouldn't finish with any
             response = self.api_response(api_version=api_version)
-            assert '/courses/{}/jump_to_id/'.format(self.course.id) in response.data['handouts_html']
+            assert f'/courses/{self.course.id}/jump_to_id/' in response.data['handouts_html']
 
     @ddt.data(
         (ModuleStoreEnum.Type.mongo, API_V05),
@@ -206,7 +206,7 @@ class TestHandouts(MobileAPITestCase, MobileAuthTestMixin, MobileCourseAccessTes
 
             # but shouldn't finish with any
             response = self.api_response(api_version=api_version)
-            assert '/courses/{}/'.format(self.course.id) in response.data['handouts_html']
+            assert f'/courses/{self.course.id}/' in response.data['handouts_html']
 
     def add_mobile_available_toy_course(self):
         """ use toy course with handouts, and make it mobile_available """
diff --git a/lms/djangoapps/mobile_api/users/tests.py b/lms/djangoapps/mobile_api/users/tests.py
index 4f3a0d7f4f..97b7608c2f 100644
--- a/lms/djangoapps/mobile_api/users/tests.py
+++ b/lms/djangoapps/mobile_api/users/tests.py
@@ -126,9 +126,9 @@ class TestUserEnrollmentApi(UrlResetMixin, MobileAPITestCase, MobileAuthUserTest
         assert len(courses) == 1
 
         found_course = courses[0]['course']
-        assert 'courses/{}/about'.format(self.course.id) in found_course['course_about']
-        assert 'course_info/{}/updates'.format(self.course.id) in found_course['course_updates']
-        assert 'course_info/{}/handouts'.format(self.course.id) in found_course['course_handouts']
+        assert f'courses/{self.course.id}/about' in found_course['course_about']
+        assert f'course_info/{self.course.id}/updates' in found_course['course_updates']
+        assert f'course_info/{self.course.id}/handouts' in found_course['course_handouts']
         assert found_course['id'] == str(self.course.id)
         assert courses[0]['mode'] == CourseMode.DEFAULT_MODE_SLUG
         assert courses[0]['course']['subscription_id'] == self.course.clean_id(padding_char='_')
@@ -237,7 +237,7 @@ class TestUserEnrollmentApi(UrlResetMixin, MobileAPITestCase, MobileAuthUserTest
 
         response = self.api_response(api_version=api_version)
         response_discussion_url = response.data[0]['course']['discussion_url']
-        assert '/api/discussion/v1/courses/{}'.format(self.course.id) in response_discussion_url
+        assert f'/api/discussion/v1/courses/{self.course.id}' in response_discussion_url
 
     @ddt.data(API_V05, API_V1)
     def test_org_query(self, api_version):
diff --git a/lms/djangoapps/monitoring/scripts/generate_code_owner_mappings.py b/lms/djangoapps/monitoring/scripts/generate_code_owner_mappings.py
index 2a284e5db6..9d5ce01f82 100644
--- a/lms/djangoapps/monitoring/scripts/generate_code_owner_mappings.py
+++ b/lms/djangoapps/monitoring/scripts/generate_code_owner_mappings.py
@@ -111,7 +111,7 @@ def main(repo_csv, app_csv, dep_csv):
     # NB: An automated script looks for this comment when updating config files,
     # so please update regenerate_code_owners_config.py in jenkins-job-dsl-internal
     # if you change the comment format here.
-    print('# Do not hand edit CODE_OWNER_MAPPINGS. Generated by {}'.format(os.path.basename(__file__)))
+    print(f'# Do not hand edit CODE_OWNER_MAPPINGS. Generated by {os.path.basename(__file__)}')
     print('CODE_OWNER_MAPPINGS:')
     for owner, path_list in sorted(owner_to_paths_map.items()):
         print(f"  {owner}:")
@@ -120,7 +120,7 @@ def main(repo_csv, app_csv, dep_csv):
             print(f"  - {path}")
 
     owner_with_mappings_set = set(owner_to_paths_map.keys())
-    print('# Do not hand edit CODE_OWNER_THEMES. Generated by {}'.format(os.path.basename(__file__)))
+    print(f'# Do not hand edit CODE_OWNER_THEMES. Generated by {os.path.basename(__file__)}')
     print('CODE_OWNER_THEMES:')
     for theme, owner_list in sorted(owner_map['theme_to_owners_map'].items()):
         theme_owner_set = set(owner_list)
diff --git a/lms/djangoapps/program_enrollments/api/tests/test_linking.py b/lms/djangoapps/program_enrollments/api/tests/test_linking.py
index a3f3d34d98..8c74fa9a51 100644
--- a/lms/djangoapps/program_enrollments/api/tests/test_linking.py
+++ b/lms/djangoapps/program_enrollments/api/tests/test_linking.py
@@ -121,7 +121,7 @@ class TestLinkProgramEnrollmentsMixin:
             program_course_enrollment.course_enrollment
             for program_course_enrollment in program_course_enrollments
         ]
-        assert all((course_enrollment.is_active for course_enrollment in course_enrollments))
+        assert all(course_enrollment.is_active for course_enrollment in course_enrollments)
         self.assertCountEqual(
             course_keys,
             [course_enrollment.course.id for course_enrollment in course_enrollments]
diff --git a/lms/djangoapps/program_enrollments/rest_api/v1/tests/test_views.py b/lms/djangoapps/program_enrollments/rest_api/v1/tests/test_views.py
index 09baa4f7ff..b616c6f9c9 100644
--- a/lms/djangoapps/program_enrollments/rest_api/v1/tests/test_views.py
+++ b/lms/djangoapps/program_enrollments/rest_api/v1/tests/test_views.py
@@ -2096,7 +2096,7 @@ class ProgramCourseEnrollmentOverviewGetTests(
     def test_course_run_url(self):
         self.log_in()
 
-        course_run_url = 'http://testserver/courses/{}/course/'.format(str(self.course_id))
+        course_run_url = f'http://testserver/courses/{str(self.course_id)}/course/'
 
         response_status_code, response_course_runs = self.get_status_and_course_runs()
         assert status.HTTP_200_OK == response_status_code
@@ -2130,7 +2130,7 @@ class ProgramCourseEnrollmentOverviewGetTests(
         course_run_overview = response_course_runs[0]
 
         assert course_run_overview['course_run_id'] == str(self.course_id)
-        assert course_run_overview['display_name'] == '{} Course'.format(str(self.course_id))
+        assert course_run_overview['display_name'] == f'{str(self.course_id)} Course'
 
     def test_emails_enabled(self):
         self.log_in()
diff --git a/lms/djangoapps/support/views/enrollments.py b/lms/djangoapps/support/views/enrollments.py
index 92b9e58594..ff314e4b84 100644
--- a/lms/djangoapps/support/views/enrollments.py
+++ b/lms/djangoapps/support/views/enrollments.py
@@ -99,7 +99,7 @@ class EnrollmentSupportListView(GenericAPIView):
                     old_mode=old_mode
                 ))
         except KeyError as err:
-            return HttpResponseBadRequest('The field {} is required.'.format(str(err)))
+            return HttpResponseBadRequest(f'The field {str(err)} is required.')
         except InvalidKeyError:
             return HttpResponseBadRequest('Could not parse course key.')
         except (CourseEnrollment.DoesNotExist, User.DoesNotExist):
diff --git a/lms/djangoapps/teams/tests/test_views.py b/lms/djangoapps/teams/tests/test_views.py
index b306e1d1f2..42d5d651ae 100644
--- a/lms/djangoapps/teams/tests/test_views.py
+++ b/lms/djangoapps/teams/tests/test_views.py
@@ -2951,7 +2951,7 @@ class TestBulkMembershipManagement(TeamAPITestCase):
         team1 = 'team wind power'
         team2 = 'team 2'
         for name_enum in enumerate(['a', 'b', 'c', 'd', 'e', 'f', 'g']):
-            username = 'user_{}'.format(name_enum[1])
+            username = f'user_{name_enum[1]}'
             self.create_and_enroll_student(username=username, mode=CourseMode.MASTERS)
             csv_content += f'{username},masters,{team1},{team2}' + '\n'
 
@@ -2964,7 +2964,7 @@ class TestBulkMembershipManagement(TeamAPITestCase):
             data={'csv': csv_file}, user='staff'
         )
         response_text = json.loads(response.content.decode('utf-8'))
-        assert response_text['errors'][0] == 'New membership for team {} would exceed max size of {}.'.format(team1, 3)
+        assert response_text['errors'][0] == f'New membership for team {team1} would exceed max size of {3}.'
 
     def test_deletion_via_upload_csv(self):
         # create a team membership that will be used further down
diff --git a/lms/djangoapps/verify_student/management/commands/manual_verifications.py b/lms/djangoapps/verify_student/management/commands/manual_verifications.py
index 603d654a24..3dcdf98ad8 100644
--- a/lms/djangoapps/verify_student/management/commands/manual_verifications.py
+++ b/lms/djangoapps/verify_student/management/commands/manual_verifications.py
@@ -63,7 +63,7 @@ class Command(BaseCommand):
                 len(failed_emails),
                 total_emails
             ))
-            log.error('Failed emails:{}'.format(pformat(failed_emails)))
+            log.error(f'Failed emails:{pformat(failed_emails)}')
         else:
             log.info(f'Successfully generated manual verification for {total_emails} emails.')
 
diff --git a/lms/djangoapps/verify_student/management/commands/retry_failed_photo_verifications.py b/lms/djangoapps/verify_student/management/commands/retry_failed_photo_verifications.py
index 79c1912f6e..d7311a5b45 100644
--- a/lms/djangoapps/verify_student/management/commands/retry_failed_photo_verifications.py
+++ b/lms/djangoapps/verify_student/management/commands/retry_failed_photo_verifications.py
@@ -69,7 +69,7 @@ class Command(BaseCommand):
             attempts_to_retry = SoftwareSecurePhotoVerification.objects.filter(status='must_retry')
             force_must_retry = False
 
-        log.info("Attempting to retry {} failed PhotoVerification submissions".format(len(attempts_to_retry)))
+        log.info(f"Attempting to retry {len(attempts_to_retry)} failed PhotoVerification submissions")
         for index, attempt in enumerate(attempts_to_retry):
             log.info(f"Retrying submission #{index} (ID: {attempt.id}, User: {attempt.user})")
 
diff --git a/lms/djangoapps/verify_student/management/commands/tests/test_manual_verify_student.py b/lms/djangoapps/verify_student/management/commands/tests/test_manual_verify_student.py
index b6dd092267..578573d53a 100644
--- a/lms/djangoapps/verify_student/management/commands/tests/test_manual_verify_student.py
+++ b/lms/djangoapps/verify_student/management/commands/tests/test_manual_verify_student.py
@@ -114,4 +114,4 @@ class TestVerifyStudentCommand(TestCase):
         Verify command raises the CommandError for invalid file path.
         """
         with pytest.raises(CommandError):
-            call_command('manual_verifications', '--email-ids-file', u'invalid/email_id/file/path')
+            call_command('manual_verifications', '--email-ids-file', 'invalid/email_id/file/path')
diff --git a/lms/djangoapps/verify_student/management/commands/tests/test_send_verification_expiry_email.py b/lms/djangoapps/verify_student/management/commands/tests/test_send_verification_expiry_email.py
index 8a821b775d..c4cde9f649 100644
--- a/lms/djangoapps/verify_student/management/commands/tests/test_send_verification_expiry_email.py
+++ b/lms/djangoapps/verify_student/management/commands/tests/test_send_verification_expiry_email.py
@@ -294,7 +294,7 @@ class TestSendVerificationExpiryEmail(MockS3BotoMixin, TestCase):
                     call_command('send_verification_expiry_email')
 
         logger.check_present(
-            (LOGGER_NAME, 'ERROR', 'Could not send email for verification id {}'.format(verifications[0].id)),
+            (LOGGER_NAME, 'ERROR', f'Could not send email for verification id {verifications[0].id}'),
         )
 
         for verification in verifications:
diff --git a/lms/djangoapps/verify_student/management/commands/tests/test_verify_student.py b/lms/djangoapps/verify_student/management/commands/tests/test_verify_student.py
index 05a26cac65..bf7ab735ec 100644
--- a/lms/djangoapps/verify_student/management/commands/tests/test_verify_student.py
+++ b/lms/djangoapps/verify_student/management/commands/tests/test_verify_student.py
@@ -77,7 +77,7 @@ class TestVerifyStudentCommand(MockS3BotoMixin, TestVerificationBase):
                     log.check_present(
                         (
                             LOGGER_NAME, 'INFO',
-                            'Attempting to retry {} failed PhotoVerification submissions'.format(1)
+                            f'Attempting to retry {1} failed PhotoVerification submissions'
                         ),
                     )
 
diff --git a/lms/djangoapps/verify_student/services.py b/lms/djangoapps/verify_student/services.py
index 711c75368b..768162f587 100644
--- a/lms/djangoapps/verify_student/services.py
+++ b/lms/djangoapps/verify_student/services.py
@@ -238,5 +238,5 @@ class IDVerificationService:
         """
         location = f'{settings.ACCOUNT_MICROFRONTEND_URL}/id-verification'
         if course_id:
-            location += '?course_id={}'.format(quote(str(course_id)))
+            location += f'?course_id={quote(str(course_id))}'
         return location
diff --git a/lms/djangoapps/verify_student/ssencrypt.py b/lms/djangoapps/verify_student/ssencrypt.py
index 47bc243e9c..1d4ddea169 100644
--- a/lms/djangoapps/verify_student/ssencrypt.py
+++ b/lms/djangoapps/verify_student/ssencrypt.py
@@ -24,7 +24,6 @@ import logging
 import os
 from hashlib import md5, sha256
 
-import six
 from cryptography.hazmat.backends import default_backend
 from cryptography.hazmat.primitives import serialization
 from cryptography.hazmat.primitives.asymmetric.padding import MGF1, OAEP
@@ -93,8 +92,8 @@ def random_aes_key():
 def pad(data):
     """ Pad the given `data` such that it fits into the proper AES block size """
 
-    if six.PY3 and not isinstance(data, (bytes, bytearray)):
-        data = six.b(data)
+    if not isinstance(data, (bytes, bytearray)):
+        data = data.encode()
 
     padder = PKCS7(AES.block_size).padder()
     return padder.update(data) + padder.finalize()
@@ -185,7 +184,7 @@ def signing_format_message(method, headers_dict, body_dict):
     will return a str that represents the normalized version of this messsage
     that will be used to generate a signature.
     """
-    headers_str = "{}\n\n{}".format(method, header_string(headers_dict))
+    headers_str = f"{method}\n\n{header_string(headers_dict)}"
     body_str = body_string(body_dict)
     message = headers_str + body_str
 
diff --git a/lms/djangoapps/verify_student/tests/test_views.py b/lms/djangoapps/verify_student/tests/test_views.py
index fc1ab4ce00..883aef9e61 100644
--- a/lms/djangoapps/verify_student/tests/test_views.py
+++ b/lms/djangoapps/verify_student/tests/test_views.py
@@ -115,7 +115,7 @@ class StartView(TestCase):
     """
 
     def start_url(self, course_id=""):
-        return "/verify_student/{}".format(urllib.parse.quote(course_id))
+        return f"/verify_student/{urllib.parse.quote(course_id)}"
 
     def test_start_new_verification(self):
         """